凯时kb88集团网址娱乐

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Professor Carreira's research program focuses on the asymmetric synthesis of biologically active, stereochemically complex, natural products. Target molecules are selected which pose unique challenges in asymmetric bond construction. A complex multistep synthesis endeavor provides a goal-oriented setting within which to engage in reaction innovation and design. Drawing from the areas of organometallic chemistry, coordination chemistry, and molecular recognition, Carreira's group is developing catalytic and stoichiometric reagents for asymmetric stereocontrol.

Carreira Group Ticino 2019
Carreira Group Ticino 2019

凯时kb88集团网址娱乐

Check out these recent publications from the Carreira lab:

M. Brandstätter, N. Huwyler, E.M. Carreira, Chem. Sci. 2019, Advanced Article. Gold(I)-catalyzed stereoselective cyclization of 1,3-enyne aldehydes by a 1,3-acyloxy migration/Nazarov cyclization/aldol addition cascade.

T. Sandmeier, F.W. Goetzke, S. Krautwald, E.M. Carreira, J. Am. Chem. Soc. 2019, 141, 12212–12218. Iridium-Catalyzed Enantioselective Allylic Substitution with Aqueous Solutions of Nucleophiles.

S.L. Rössler, D.A. Petrone, E.M. Carreira, Acc. Chem. Res. 2019, asap. Iridium-Catalyzed Asymmetric Synthesis of Functionally Rich Molecules Enabled by (Phosphoramidite,Olefin) Ligands.

P. Sondermann, E.M. Carreira, J. Am. Chem. Soc., 2019, 141, 10510–10519. Stereochemical Revision, Total Synthesis, and Solution State Conformation of the Complex Chlorosulfolipid Mytilipin B.

Y. Sempere, J.L. Alfke, S.L. Rössler, E.M. Carreira, Angew. Chem. Int. Ed., 2019, 58, 9537–9541Morpholine Ketene Aminal as Amide Enolate Surrogate in Iridium‐Catalyzed Asymmetric Allylic Alkylation.

B.S. Schreib, E.M. Carreira, J. Am. Chem. Soc., 2019, 141, 8758–8763. Palladium-Catalyzed Regioselective C−H Iodination of Unactivated Alkenes.

M. Isomura, D.A. Petrone, E.M. Carreira, J. Am. Chem. Soc., 2019, 141, 4738–4748. Coordination-Induced Stereocontrol over Carbocations: Asymmetric Reductive Deoxygenation of Racemic Tertiary Alcohols.

M. Brandstätter, M. Freis, N. Huwyler, E.M. Carreira, Angew. Chem. Int. Ed., 2019, 58, 2490–2494Total Synthesis of (–)‐Merochlorin A.

S.L. Rössler, B.J. Jelier, P.F. Tripet, A. Shemet, G. Jeschke, A. Togni, E.M. Carreira, Angew. Chem. Int. Ed. 2019, 131, 536 –541. Pyridyl Radical Cation for C–H Amination of Arenes.

J. Boshkow, T. Scattolin, F. Schoenebeck, E.M. Carreira, Helv. Chim. Acta 2018, 101, e18001. [1,3]‐Sigmatropic Shift of an Allylic Chloride.

M.J.R. Richter, M. Schneider, M. Brandstätter, S. Krautwald, E.M. Carreira, J. Am. Chem. Soc., 2018, 140, 16704–16710. Total Synthesis of (–)-Mitrephorone A.

A. Chicca, M.A. Schafroth, I. Reynoso-Moreno, R. Erni, V. Petrucci, E.M. Carreira, J. Gertsch, Sci. Adv. 2018, 4, 1–10. Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high.

J.F. Teiber, J. Xiao, G.L. Kramer, S. Ogawa, C. Ebner, H. Wolleb, E.M. Carreira, D.M. Shih, R.W. Haley, Biochem. Biophys. Res. 2018, 505, 87–92. Identification of biologically active δ-lactone eicosanoids as paraoxonase substrates.

A.G. Kravina, E.M. Carreira, Angew. Chem. Int. Ed. 2018, 57, 13159–13162. Total Synthesis of Epicolactone.

N.Hauser, P. Kraft, E.M. Carreira, Synthesis 2018, 50,4490–4500. Unconventional Rose Odorants: Serendipitous Discovery and Unique Olfactory Properties of 2,2-Bis(prenyl)-3-oxobutyronitrile and Its Derivatives.

Y. Sempere, E.M. Carreira, Angew. Chem. Int. Ed., 2018, 57, 7654–7658. Trimethyl Orthoacetate and Ethylene Glycol Mono-Vinyl Ether as Enolate Surrogates in Enantioselective Iridium-Catalyzed Allylation.

H. Wolleb, S. Ogawa, M. Schneider, A. Shemet, J. Muri, M. Kopf, E.M. Carreira, Org. Lett., 201820, 3014−3016. Synthesis and Structure–Activity Relationship Studies of Anti-Inflammatory Epoxyisoprostane Analogues.

N. Sobotzki, M.A. Schafroth, A. Rudnicka, A. Koetemann, F. Marty, S. Goetze, Y. Yamauchi, E.M. Carreira, B. Wollscheid, Nat. Comm. 2018, 9, 1519. HATRIC-based identification of receptors for orphan ligands.

N. Sievertsen, E.M. Carreira, Chimia 2018, 72, 44–47. Apoc Social: A Mobile Interactive and Social Learning Platform for Collaborative Solving of Advanced Problems in Organic Chemistry.

D.A. Petrone, M. Isomura, I. Franzoni, S.L. Rössler, E.M. Carreira, J. Am. Chem. Soc. 2018, 140, 4697–4704. Allenylic Carbonates in Enantioselective Iridium-Catalyzed Alkylations.

E.M. Carreira, J. Isr. Chem. 2018, 59, 114–121. Natural Products Synthesis: A Personal Retrospective and Outlook.

M. Soethoudt, S.C. Stolze, M.V. Westphal, L. van Stralen, A. Martella, E.J. van Rooden, W. Guba, Z.V. Varga, H. Deng, S.I. van Kasteren, U. Grether, A.P. IJzerman, P. Pacher, E.M. Carreira, H.S. Overkleeft, A. Ioan-Facsinay, L.H. Heitman, M. van der Stelt, J. Am. Chem. Soc. 2018, 140, 6067–6075. Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells.

L.J. Nannini, Suren J.Nemat, E.M. Carreira, Angew. Chem. Int. Ed., 2018, 130, 831–834. Total Synthesis of (+)-Sarcophytin.

M.V. Westphal, M.A. Schafroth, R.C. Sarott, M.A. Imhof, C.P. Bold, P. Leippe, A. Dhopeshwarkar, J.M. Grandner, V. Katritch, K. Mackie, D. Trauner, E.M. Carreira, J.A. Frank, J. Am. Chem. Soc. 2017, 139, 18206–18212. Synthesis of Photoswitchable Δ9-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling.